Hormone 'to restart reproduction'

A team of UK scientists says a recently discovered hormone could potentially form the basis of an effective and less risky fertility treatment.

Kisspeptin could restore reproductive function in women with low sex hormone levels whose system has shut down, says the team from Imperial College London.

The hormone plays a key role in stimulating release of the hormones which control the menstrual cycle.

The study was presented at a Society for Endocrinology conference.

Humans and animals lacking kisspeptin do not go through puberty and remain sexually immature.

In a previous study, the researchers, from Imperial College London, showed that kisspeptin treatment leads to the production of sex hormones in fertile women.

Now they have now extended their research to look at the effects of kisspeptin in women whose periods have stopped owing to a hormone imbalance.

In the latest study, a group of 10 women who were not menstruating and were infertile were injected with either kisspeptin or a saline solution.

Blood samples were then taken to measure their levels of two key hormones essential for ovulation and fertility - luteinising hormone (LH) and follicle stimulating hormone (FSH).

Compared to the placebo treatment, kisspeptin led to a 48-fold increase in LH and 16-fold increase in FSH.

Lead researcher Dr Waljit Dhillo said kisspeptin treatment stimulated a greater increase in LH production in non-menstruating women than in fertile women in the previous study.

He said: "Infertility is a devastating condition that affects millions of couples worldwide.

"This is a very exciting result and suggests that kisspeptin treatment could restore reproductive function in women with low sex hormone levels.

Subtle effect

Our future research will focus on determining the best protocol for repeated kisspeptin administration with the hope of developing a new therapy for infertility."

Professor Richard Anderson, a fertility expert at the University of Edinburgh, said the research held the promise of a more effective and subtle way of treating women whose reproductive systems had effectively closed down.

He said most current treatments involved directly stimulating the ovaries, which carried a risk both of multiple pregnancies and side effects.

In contrast, the use of a therapy based on kisspeptin would potentially address the underlying problem, effectively re-awakening the reproductive system, while - unlike alternative treatments - ensuring the body's own protective regulatory mechanisms remained in place.

Professor Anderson said: "This is one of the most interesting new hormones that has been discovered for a very long time, and in time it may well become a mainstream part of therapy."

Overweight, shorter lifespan

PARIS - SIMPLY being overweight, but not obese, from an early age boosts the risk of premature death by a third - as much as smoking up to 10 cigarettes a day, researchers in Sweden reported Wednesday.

People who are clinically obese by the age of 18 more than double that risk, putting themselves in the same danger zone as long-term heavy smokers of normal weight, they found. And combining the two factors accumulates the risk: an obese heavy smoker, for example, is nearly five times as likely to die prematurely than a non-smoker who is neither too thin nor too fat.

At least a billion people in the world are overweight, and nearly a third of them are obese, according to the World Health Organisation (WHO). Obesity rates have soared over the last three decades, especially among children.

Earlier studies have shown that being excessively fat shortens lifespan and leads to increased rates of chronic disease such as diabetes and arteriosclerosis.

But researchers have disagreed sharply up to now on whether being above ideal weight without crossing the line to obesity takes years off one's life. Nor have previous studies directly compared the impact on mortality of smoking and excess weight.

The study designed by Martin Neovius of the Karolinska Institute in Stockholm goes a long way to settling the debate, and shows clearly for the first time that being too heavy can be as dangerous as smoking a couple of packs a day.

Mr Neovius and colleagues analysed data for 45,000 men who underwent mandatory military conscription tests in Sweden in 1969 and 1970 at the age of 18.

The follow up period was, on average, 38 years. During that time, 2,897 subjects died. The lowest death rate, as expected, was among non-smokers of normal weight.

But researchers were surprised to find that being obese carried a greater risk of premature death than being a heavy smoker. Even more startling, however, were the dangers of being overweight. 'What we show is that for the overweight, there is a significantly increased risk of premature death, similar to smoking one-to-ten cigarettes a day,' said Mr Neovius in a phone interview.

The Swedish study also found that being severely underweight - a BMI of under 17 - carried about the same risk of early death as being overweight or a light smoker. -- AFP

Breast Cancer

One in every nine women in the UK will develop breast cancer at some point in her life - more than 41,000 cases are diagnosed each year.

It has become the most common cancer in the UK, and is the leading cause of death for women aged 34 to 54.

More rarely, men can also develop this cancer.

Despite recent improvements in the mortality rates, due to better treatments and earlier detection, the UK still has one of the highest mortality rates in the world.

But research is beginning to reap dividends in new ways of understanding how breast cancer cells work.

Professor Charles Coombes, who is director of Cancer Research UK's research laboratory at Imperial College London, says there is cause for optimism.

"The more we understand about how these cells behave, the more likely we are to understand what happens with breast cancer.

"That revolution is ongoing. We are going, I think, to be looking at improved results over the next 20 or 30 years."

Symptoms

The most common way that a potential problem is detected is when physical changes are noticed in the breasts.

Regular breast screening may also highlight changes in the breast.

The key is for the woman to know what "normal" is - then changes can be noticed.

Examples of the kind of things to look out for include:

* a change in outline, shape or size of the breast
* puckering or dimpling of the skin
* any lump or thickening in the breast or armpit
* any flaking skin or discharge from the nipple
* unusual pain or discomfort

Any changes should be reported to a doctor - although most will turn out not to be cancerous.

Many lumps will be picked up with mammograms - x-rays of the breast taken every few years as part of the NHS national screening programme.

If a lump is found, techniques used to investigate it include ultrasound and "fine needle aspiration", which will show whether the area is a solid lump or is a cyst.

A biopsy may also be carried out, so that a sample of the lump can be examined in a laboratory.

Causes

The precise reasons why a woman develops breast cancer are still unknown, but are thought to be a combination of genetic, environmental and lifestyle factors.

Scientists have identified two genes which are more likely to be defective in a breast cancer patient than someone without breast cancer.

These genes are also blamed for some other cancers.

However, even the two mutated genes are thought only to be responsible for approximately 5% to 10% of breast cancer cases.

Hormones seem to have an important role in breast cancer. Research has shown a link between levels of the female sex hormone, oestrogen, and the risk of developing breast cancer.

Women who take certain types of hormone replacement therapy are at higher risk of breast cancer.

Women who have their first child later in life also appear to be at higher risk of developing breast cancer.

Treatments

If cancer is confirmed, then there are variety of treatments available, depending on the size of type of the tumour, and whether doctors believe it has or could have spread.

Most women with breast cancer do not need to have a breast removed.

The bigger the tumour relative to the size of the breast, the more likely that mastectomy will be recommended.

In a procedure known as a "lumpectomy", just the cancerous lump is removed.

After both kinds of operation, radiotherapy may be given to reduce the chance that the cancer will return.

If the tumour is very large, treatment may be given to reduce the size of the tumour before the operation takes place.

In most cases, the surgeon also removes lymph nodes under the arms to find out if the cancer cells have spread into the lymphatic system.

This is a network of vessels which link different parts of the body - if the cancer has reached the lymph nodes, it is more likely to have spread to other parts of the body.

The breast cancer cells may be tested to see if they are sensitive to the sex hormone oestrogen, and are more likely to grow if the hormone is present.

If this is the case, the woman may be given a drug which blocks the action of the hormone, restricting the cancer growth.

However, as some forms of this drug produce menopausal symptoms, younger women whose breast cancer is more likely to have spread could be offered a combination of surgery and chemotherapy instead.

Following breast surgery, or even breast removal, reconstructive surgery is possible to restore the appearance of the breast.

This could even be carried out at the same time as mastectomy.

Techniques have improved in recent years, and surgeons are able to more closely mimic the appearance of the other breast, giving a normal appearance in clothes.

Some of the techniques employed include the use of implants, fat from other parts of the body, such as the tummy, or even a back muscle which is bent round to form the new breast.