Wednesday, June 16, 2010

Viable option for leukemia

CHICAGO - ADULT patients with leukemia fare just as well when they get stem cell transplants taken from a cord blood bank as they do from a well-suited adult donor, US researchers said on Tuesday.

They said umbilical cord transplants are a viable option for adults with leukemia who urgently need a bone marrow transplant to replace cells destroyed by chemotherapy or radiation treatments, but cannot find a donor.

'What we found is when you look at the outcome of leukemia-free survival, which is the likelihood of a patient being alive without disease, it's the same whether you are transplanting using an adult graft which is from an adult donor or a cord blood unit,' said Dr Mary Eapen of the Medical College of Wisconsin, whose study appears in the journal Lancet Oncology.

Cord blood worked even if it was not a great match, Dr Eapen said in a telephone interview. Only about half of all white adult patients can find a suitable donor, and the odds are much lower if the patient is African American or Asian, Dr Eapen said.

'In general ... if you don't have an acceptable tissue match with a donor, your chances of having a complication are higher and it can result in death,' she said.

But that is less so with stem cells from umbilical cord blood. 'The body is more tolerant to the cells in the placental blood, even though they are not a perfect match.' Dr Eapen and colleagues analysed data from 216 transplant centers worldwide. They compared the results of 165 patients 16 or older with acute leukemia who had been received umbilical cord blood to 888 adults given unrelated stem cell transplants, and 472 who had been given unrelated donor bone marrow. -- REUTERS

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