In this one year study on 12 Japanese women it was shown that grape seed extract has a lightening effect on melasma and effectively reduced hyper-pigmentation and that final results were achieved after 6 months of intake.
In a study on guinea pigs, the oral intake of grapeseed extract showed to have a marked lightening effect on the skin where the skin had pigmentation induced by ultra violet rays - like those of the sun. In this study, a control was kept with some of the other guinea pigs being given vitamin C instead - but they did not show and reduced pigmentation - therefore - it can be concluded that it is not the antioxidant effect that resulted in the skin lightening, but was due to anther pathway.
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